HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5-(3-Methoxyphenylethynyl)-pyridine-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-Bromo-5-(3-methoxyphenylethynyl)-pyridine | HCID 67047513 | — |
| Reactant | HCID 178418918 | HCID 178418918 | — |
| Product | 5-(3-Methoxyphenylethynyl)-pyridine-3-carbaldehyde | HCID 86076459 | 82% |
Reaction Steps
Prepare essentially as described in EXAMPLE 90 using a 1 M solution of isopropylmagnesium chloride in tetrahydrofuran (2.98 mL, 2.98 mmol), 3-bromo-5-(3-methoxyphenylethynyl)-pyridine, (prepared as described in PREPARATION 20), (430 mg, 1.49 mmol) to give the title compound (290 mg, 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915424B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-3d79a13a22dc415eb639201a1f45c912 |
| Source note | uspto-grants-2011_03 |