HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Methylhydroxylamine hydrochloride → (E)-N-methoxy-1-[5-[2-(3-methoxyphenyl)ethynyl]-3-pyridinyl]methanimine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | 5-(3-Methoxyphenylethynyl)-pyridine-3-carbaldehyde | HCID 86076459 | — |
| Product | (E)-N-methoxy-1-[5-[2-(3-methoxyphenyl)ethynyl]-3-pyridinyl]methanimine | HCID 87248507 | 78% |
Reaction Steps
Prepare essentially as described in EXAMPLE 6 using 5-(3-methoxyphenylethynyl)-pyridine-3-carbaldehyde, (prepared essentially as described in EXAMPLE 91), (290 mg, 1.22 mmol) and methoxylamine hydrochloride (520 mg, 9.78 mmol). The E/Z Isomers were separated during the purification to give the title compound (254 mg, 78%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915424B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-5be0eed0030d49fc8fa5beb98dc5094d |
| Source note | uspto-grants-2011_03 |