HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-(4-Fluorophenylethynyl)-pyridine-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-Bromo-5-(4-fluorophenylethynyl)-pyridine | HCID 67047615 | — |
| Reactant | HCID 178418918 | HCID 178418918 | — |
| Product | 5-(4-Fluorophenylethynyl)-pyridine-3-carbaldehyde | HCID 86076470 | 24% |
Reaction Steps
Prepare in a similar manner as described in EXAMPLE 90, using a 2 M solution of isopropylmagnesium chloride in tetrahydrofuran (2.99 mL, 5.98 mmol), 3-bromo-5-(4-fluorophenylethynyl)-pyridine (1.50 g, 5.43 mmol), (prepared essentially as described in EXAMPLE 96), and anhydrous N,N-dimethylformamide (1.99 g, 27.16 mmol) to give the title compound (0.29 g, 24%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915424B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-0fbfbc71b9504dfcb13a38ab6e4b5497 |
| Source note | uspto-grants-2011_03 |