HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-5-trimethylsilanylethynyl-phenylamine → 5-(3-Amino-4-fluorophenylethynyl)-nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-5-trimethylsilanylethynyl-phenylamine | HCID 67047696 | — |
| Reactant | 3-Bromonicotinonitrile | HCID 67047774 | — |
| Product | 5-(3-Amino-4-fluorophenylethynyl)-nicotinonitrile | HCID 67047822 | 65% |
Reaction Steps
Prepare essentially as described in EXAMPLE 138 using 3-bromonicotinonitrile (3.4 g, 18.3 mmol) and 2-fluoro-5-trimethylsilanylethynyl-phenylamine, (prepared as described in PREPARATION 41), (3.8 g, 18.3 mmol) to give the title compound as a white solid (2.8 g, 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915424B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-00547915240f429085bf9f6c5be4190d |
| Source note | uspto-grants-2011_03 |