反应详情

Add Lawesson's Reagent, [2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphate -2,4-disulfide], (0.42 g, 1.03 mmol) to a suspension of 5-phenylethynyl-nicotinamide (0.12 g, 0.52 mmol) in toluene (3 mL) and stir for 48 h. Concentrate the reaction mixture and purify the residue by silica gel chromatography, eluting with 10:90 to 60:40 with ethyl acetate:hexanes, to give the title compound as a pale yellow solid (0.05 g, 40%).

1. concentrationConcentrate the reaction mixture
2. custompurify the residue by silica gel chromatography
3. washeluting with 10:90 to 60:40 with ethyl acetate