Acetic Anhydride → HCID 67047834, compound

HRID 606941Notes

Reaction equation

HRID 606941 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([O:16][CH3:17])[CH:15]=2)=[CH:4][C:3]=1[NH2:18].[C:19](OC(=O)C)(=[O:21])[CH3:20]>N1C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([O:16][CH3:17])[CH:15]=2)=[CH:4][C:3]=1[NH:18][C:19](=[O:21])[CH3:20]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 67047543HCID 67047543, compound

Product 1

HCID 67047834HCID 67047834, compoundYield 76.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Dissolve 2-fluoro-5-(5-methoxypyridin-3-ylethynyl)-phenylamine, (prepared as described in EXAMPLE 111), (200 mg, 0.83 mmol) in pyridine (3 mL) and add acetic anhydride (84 mg, 0.83 mmol). Stir under nitrogen at room temperature for 48 h and concentrate. Purify by silica gel chromatography, eluting with 100% ethyl acetate to give the title compound as a light yellow solid (180 mg, 76%).

Workup

  1. concentrationconcentrate
  2. customPurify by silica gel chromatography
  3. washeluting with 100% ethyl acetate

Sources & evidence

ORD record
ord-ffed0d2626274269a4e9904eb15d5b4e
Source dataset
uspto-grants-2011_03
Patent number
US07915424B2

Reaction notes

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