HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methanesulfonic acid trans-6-benzhydryl-tetra-hydropyran-3-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Trans-6-benzhydryl-tetrahydropyran-3-ol | HCID 11608697 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methanesulfonic acid trans-6-benzhydryl-tetra-hydropyran-3-yl ester | HCID 11566406 | 78.7% |
Reaction Steps
Methanesulfonyl chloride (0.33 g, 2.87 mmol) was reacted with trans-2-diphenylmethyl-tetrahydropyran-5-ol 11 (0.38 g, 1.43 mmol) in the presence of triethylamine (0.22 g, 2.15 mmol) in methylene chloride (10 ml) to give trains-2-diphenylmethyl-tetrahydropyran-5-yl methanesulfonate 13 (0.39 g, 77.8%) as an oil (Procedure A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915433B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-0fedbb95dc6845a58bde6e7be66909f9 |
| Source note | uspto-grants-2011_03 |