HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxybenzylamine → (3R,4R,6S)-6-benzhydryl-4-(4-methoxy-benzylamino)-tetrahydropyran-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxybenzylamine | HCID 75452 | — |
| Reactant | HCID 86605349 | HCID 86605349 | — |
| Product | (3R,4R,6S)-6-benzhydryl-4-(4-methoxy-benzylamino)-tetrahydropyran-3-ol | HCID 66631579 | — |
Reaction Steps
(1R, 4S, 6S)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]heptane 28b (0.021 g, 0.079 mmol) was reacted with p-methoxybenzylamine (0.22 g, 1.58 mmol) (Procedure E) to yield (3R, 4R, 6S)-6-benzhydryl-4-(4-methoxy-benzylamino)-tetrahydropyran-3-ol, (−)-29 g 0.02 g (63%, [α]D=(−)63.75, c=1, MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915433B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-975a3efd229f4088b556315f15252fb3 |
| Source note | uspto-grants-2011_03 |