Iodine → HCID 67065998, compound

HRID 607031Notes

Reaction equation

HRID 607031 reaction equation
[I:1]I.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])=[C:7]([F:18])[CH:6]=1>CO.S([O-])([O-])(=O)=O.[Ag+2]>[CH3:3][O:4][C:5]1[C:10]([I:1])=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])=[C:7]([F:18])[CH:6]=1

Participants

5

Reactant 2

HCID 807IodineHCID 670659662-Fluoro-4-methoxy-1-(2-methylphenyl)benzene

Product 1

HCID 67065998HCID 67065998, compound

Reagents, catalysts & solvents 2

HCID 178418844HCID 178418844, compoundCatalystHCID 887MethanolSolvent2×

Procedure

To a mixture of silver sulfate (0.34 g, 1.11 mmol), iodine (0.28 g, 1.11 mmol) in MeOH (10 ml) at room temperature, a solution of 2-fluoro-2′-methylbiphenyl-4-yl methyl ether from above (0.24 g, 1.11 mmol) in MeOH (5 ml) was added dropwise. The mixture was stirred at room temperature for 4 h until the color turned to light yellow. The solid was filtered off and the filtrate was concentrated. The residue was purified via flash column using hexane as the eluant to give the title compound.

Workup

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified via flash column

Sources & evidence

ORD record
ord-08e82a03727345aa8f7ad123568aa190
Source dataset
uspto-grants-2011_03
Patent number
US07915271B2

Reaction notes

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