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HRID60709

反应详情

EQUATION

反应方程式

HRID 60709 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)OC(C1CC1)[C@@H]1C[C@H](CC(=O)[O-])[C@H](n2c(=O)sc3cnc(N)nc32)O1
HCID131737100

未命名化合物

2 次

结构：CCC(OC(C)=O)[C@@H]1C[C@H](CC(=O)[O-])[C@H](n2c(=O)sc3cnc(N)nc32)O1
HCID131737101

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)O[C@@H](C1CC1)[C@@H]1C[C@@H](O)[C@H](n2c(=O)sc3cnc(N)nc32)O1
HCID121396321

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to Example 4, by using [(2R,3R,5S)-5-[acetoxy(cyclopropyl)methyl]-2-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)tetrahydrofuran-3-yl] acetate (compound 16a) instead of [(2R,3R,5S)-5-(1-acetoxypropyl)-2-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)tetrahydrofuran-3-yl]acetate (compound 2a). Example 16 was purified and separated by preparative HPLC to afford Example 16-A and Example 16-B as white solid.

WORKUP

后处理

  1. customExample 16 was purified
  2. customseparated by preparative HPLC