Iodide Ion → HCID 57692979, compound

Participants

Reaction Steps

methyl 2-chloro-2′-fluoro-4′-methoxybiphenyl-4-carboxylate (550 mg, 1.87 mmol), methanol (8 mL), iodide (474 mg, 1.87 mmol) and silver sulfate (583 mg, 1.87 mmol) were stirred at room temperature for 2 hours. Reaction crude was worked up with NaHSO3 (aq). Volatiles were removed under reduced pressure. The pot residue was worked up with brine, extracted with ethyl acetate, dried over Na2SO4, filtered and evaporated to afford a light brown solid. This solid was purified by SiO2 (Biotage Horizon Flash system, 40+M cartridge, 0-20% EtOAc/hexanes, v/v) to afford the title compound. LCMS (ESI) calc.=419.94; found=420.86 (M+1)+.

Provenance & Evidence