Formamide → HCID 178438395, compound

HRID 607134Notes

Reaction equation

HRID 607134 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH2:12][CH2:13][CH3:14])=[CH:5][C:6]=1[C:7](OCC)=[O:8].[CH:15]([NH2:17])=O>>[CH2:12]([C:4]1[S:3][C:2]2[N:1]=[CH:15][N:17]=[C:7]([OH:8])[C:6]=2[CH:5]=1)[CH2:13][CH3:14]

Participants

3

Reactant 2

HCID 713FormamideHCID 3399457ethyl 2-amino-5-propylthiophene-3-carboxylate

Product 1

HCID 178438395HCID 178438395, compound

Procedure

The product of example 3a was reacted with excess formamide at reflux for 3 hours. The reaction mixture was quenched with water and the resulting precipitate was collected by filtration and washed with water and dried under vacuum to provide the title compound.

Workup

  1. temperatureat reflux for 3 hours
  2. customThe reaction mixture was quenched with water
  3. filtrationthe resulting precipitate was collected by filtration
  4. washwashed with water
  5. customdried under vacuum

Sources & evidence

ORD record
ord-c6f5c4d377bf43eaaff2f35ec8950d85
Source dataset
uspto-grants-2011_03
Patent number
US07915411B2

Reaction notes

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