Ammonia → 2-Thiobutyrylamino-acetamide

HRID 607138Notes

Reaction equation

HRID 607138 reaction equation
C[O:2][C:3](=O)[CH2:4][NH:5][C:6](=[S:10])[CH2:7][CH2:8][CH3:9].[NH3:12]>CO>[C:6]([NH:5][CH2:4][C:3]([NH2:12])=[O:2])(=[S:10])[CH2:7][CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86614621Thiobutyrylamino-acetic acid methyl ester

Product 1

HCID 866146222-Thiobutyrylamino-acetamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the product of Example 5B (0.788 g, 4.496 mmol) in methanol (30 mL) was saturated with ammonia gas and the reaction was stirred in a stoppered flask at room temperature for 17 hours. The solvent was concentrated under vacuum giving the title compound and the solid purified by silica gel flash chromatography with 10% methanol/methylene chloride to give the title compound as a white solid (500 mg, 3.12 mmol, 69%).

Workup

  1. concentrationThe solvent was concentrated under vacuum

Sources & evidence

ORD record
ord-61939e7f9b844ea7a393b37a008bc364
Source dataset
uspto-grants-2011_03
Patent number
US07915411B2

Reaction notes

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