HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenyl Ether → 2-Propyl-4H-thiazolo[5,4-b]pyridin-7-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | 2,2-Dimethyl-5-[(2-propyl-thiazol-5-ylamino)-methylene]-[1,3]dioxane-4,6-dione | HCID 66808315 | — |
| Product | 2-Propyl-4H-thiazolo[5,4-b]pyridin-7-one | HCID 66808507 | 83% |
Reaction Steps
The product of Example 5E (230 mg, 0.7781 mmol) was added to refluxing diphenyl ether (5 mL) under a nitrogen atmosphere. After refluxing for 5 minutes, the solution was cooled in an ice bath and diluted with hexanes (50 mL). The resulting golden solid was collected by vacuum filtration and thoroughly washed with hexanes to give the title compound (125 mg, 0.644 mmol, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915411B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-dd6f539f66534e5e83b801c3e67d02ab |
| Source note | uspto-grants-2011_03 |