4-Chloro-3-nitrophenol → HCID 60204766, compound

HRID 607178Notes

Reaction equation

HRID 607178 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].Br[CH2:13][C:14]1[S:18][C:17]([Cl:19])=[N:16][CH:15]=1>>[Cl:19][C:17]1[S:18][C:14]([CH2:13][O:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=2)=[CH:15][N:16]=1

Participants

3

Reactant 2

HCID 691274-Chloro-3-nitrophenolHCID 101305605-Bromomethyl-2-chloro-thiazole

Product 1

HCID 60204766HCID 60204766, compound

Procedure

A solution of 4-chloro-3-nitro-phenol was reacted with 5-Bromomethyl-2-chloro-thiazole (prepared according to the method of Kim, H.-J., Liu, S., Keum, Y.-S., Qing, X. J. Agric. Food Chem. 2003, 51, 1823-1830) using the conditions described in Example 10C to provide 2-Chloro-5-(4-chloro-3-nitro-phenoxymethyl)-thiazole which was treated sequentially using the procedures from Examples 10D and 10E to provide the title product.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-8b7ab1cb766e4477bfa5a2786c9f21fa
Source dataset
uspto-grants-2011_03
Patent number
US07915411B2

Reaction notes

Loading…