N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine → 4-[4-Benzyloxy-2-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol

Participants

Role	Name	HCID	Charge
Reactant	N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine	HCID 66808319	—
Reactant	4-(2-Amino-4-benzyloxy-phenylsulfanyl)-phenol	HCID 66808597	—
Reactant	4-[2-Amino-4-(3-fluoro-benzyloxy)-phenylsulfanyl]-phenol	HCID 66808677	—
Product	4-[4-Benzyloxy-2-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol	HCID 66808328	—

Reaction Steps

The product from Example 27A and the product from Example 57A were reacted according to the procedure in Example 57E substituting the product of Example 27A for the product of Example 57D to provide the title compound which was isolated as the acetic acid salt (79 mg, 48%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 5.10 (s, 3H), 6.61-6.72 (m, 2H), 6.93 (d, J=9.56 Hz, 1H), 7.11 (d, J=8.46 Hz, 4H), 7.24 (s, 1H), 7.32-7.47 (m, 5H), 7.59-7.68 (m, 1H), 8.54 (s, 1H), 8.83 (d, J=9.56 Hz, 1H), 9.04 (s, 1H); ESI+ m/z 453 (M+H)+, ESI− m/z 451 (M−H)−.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07915411B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-2a0415099af243c09d862306628765cf
Source note	uspto-grants-2011_03