Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

A solution of the product from Example 147D (38.8 mg, 0.059 mmol) and pentamethylbenzene (87 mg, 0.5901 mmol) in trifluoroacetic acid (5 mL) was stirred at room temperature for 2 hours. The solvent was removed by rotary evaporation under vacuum and co-evaporated with methylene chloride/hexanes (2×). The resulting solid was triturated with hexanes (3×) and purified by HPLC with TFA to provide the title compound as a trifluoroacetic acid salt (22 mg, 47%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.36 (d, J=6.99 Hz, 6H), 3.20-3.39 (m, 1H), 6.78 (d, J=8.82 Hz, 2H), 6.95 (d, J=9.19 Hz, 2H), 7.02 (d, J=8.82 Hz, 1H), 7.36 (dd, J=8.64, 2.02 Hz, 1H), 7.55 (d, J=8.46 Hz, 1H), 7.78 (d, J=1.47 Hz, 1H), 7.91 (d, J=8.82 Hz, 1H), 8.11 (dd, J=8.64, 2.02 Hz, 1H), 8.35 (d, J=1.84 Hz, 1H), 8.94 (s, 1H), 9.03 (d, J=8.82 Hz, 1H), 9.46 (br s, 1H), 11.63 (br s, 1H); MS (APCI+) m/z 567/569 (M+H)+.

Provenance & Evidence