HCID 66808376, compound → HCID 57469907, compound

Participants

Reaction Steps

The product from Example 147C was reacted with the product from Example 10B using the procedure described in Example 147D substituting the product from Example 10B for the product from Example 36E to provide [2-(4-Benzyloxy-phenoxy)-5-(6-bromo-1H-benzoimidazol-2-yl)-phenyl]-(7-methyl-pyrido[2,3-d]pyrimidin-4-yl)-amine which was debenzylated according to the procedure described in Example 147E to provide the crude product which was purified by HPLC with TFA to provide the title compound as a trifluoroacetic acid salt. 1H NMR (300 MHz, DMSO-D6) δ ppm: 2.74 (s, 3H), 6.77 (d, J=9.19 Hz, 2H), 6.95 (d, J=8.82 Hz, 2H), 7.01 (d, J=8.82 Hz, 1H), 7.35 (dd, J=8.46, 1.84 Hz, 1H), 7.54 (d, J=8.82 Hz, 1H), 7.74-7.85 (m, 2H), 8.10 (dd, J=8.82, 2.21 Hz, 1H), 8.36 (d, J=2.21 Hz, 1H), 8.90 (s, 1H), 8.95 (d, J=8.46 Hz, 1H), 9.45 (bs, 1H), 11.35 (bs, 1H); MS (ESI+) m/z 539/541 (M+H)+.

Provenance & Evidence