Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

The product from Example 149E (44 mg, 0.061 mmol) was treated with trifluoroacetic acid (2 mL) in methylene chloride (2 mL) at room temperature for 30 minutes. The solvents were removed by rotary evaporation under vacuum and the residual oil dried under hi-vacuum. Purification by silica gel chromatography using 5% methanol/methylene chloride as eluent provided the title compound as a trifluoroacetic acid salt (25 mg, 48%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.35 (d, J=6.62 Hz, 6H), 3.13-3.38 (m, 1H), 6.63 (d, J=8.46 Hz, 2H), 6.87 (d, J=7.72 Hz, 1H), 7.01-7.09 (d, J=8.82 Hz, 2H), 7.12 (d, J=8.46 Hz, 2H), 7.44 (d, J=8.82 Hz, 2H), 7.61 (dd, J=7.72, 1.47 Hz, 1H), 7.71 (s, 1H), 7.81 (dd, J=6.62, 1.47 Hz, 1H), 8.66-8.80 (m, 1H), 8.90 (d, J=6.99 Hz, 1H), 10.55 (s, 1H); MS (ESI+) m/z 621/623 (M+H)+.

Provenance & Evidence