Benzyl Bromide → HCID 66808377, compound

Participants

Reaction Steps

The product from Example 164 was reacted with benzyl bromide according to the procedure from Example 165 substituting benzyl bromide for bromo-acetonitrile to provide the crude product which was purified by silica gel chromatography using 98/2 dichloromethane/methanol as eluent to provide the title compound (15 mg, 29%). 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.20 (t, J=7.35 Hz, 3H), 2.27 (s, 3H), 3.08 (q, J=7.35 Hz, 2H), 5.44 (s, 2H), 6.74 (d, J=8.46 Hz, 2H), 6.95 (m, 3H), 7.20 (d, J=8.46 Hz, 2H), 7.35 (m, 5H), 8.77 (s, 1H), 9.42 (s, 1H), 9.81 (s, 1H); MS (ESI+) m/z 512 (M+H)+.

Provenance & Evidence