3-Nitrophenol → HCID 6486024, compound

HRID 607285Notes

Reaction equation

HRID 607285 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-])=O.Br[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1.BrCC1C=CC=C(F)C=1>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([CH2:12][O:10][C:6]2[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 111373-NitrophenolHCID 680073-Fluorobenzyl bromideHCID 680214-Fluorobenzyl bromide

Product 1

HCID 6486024HCID 6486024, compound

Procedure

3-Nitro-phenol was reacted with 1-bromomethyl-4-fluoro-benzene according to the procedure from Example 199A substituting 1-bromomethyl-4-fluoro-benzene for 1-bromomethyl-3-fluoro-benzene then reduced according to the procedure from Example 199B to provide the title compound.

Sources & evidence

ORD record
ord-0b9354e7b7264e1a8d213a57c6b3a7bb
Source dataset
uspto-grants-2011_03
Patent number
US07915411B2

Reaction notes

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