3-Nitrophenol → HCID 16795875, compound

HRID 607288Notes

Reaction equation

HRID 607288 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-])=O.Br[CH2:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[C:16]#[N:17].BrCC1C=CC=C(F)C=1>>[NH2:1][C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[O:10][CH2:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[C:16]#[N:17]

Participants

4

Reactant 3

HCID 111373-NitrophenolHCID 680073-Fluorobenzyl bromideHCID 97249Benzonitrile, 3-(bromomethyl)-

Product 1

HCID 16795875HCID 16795875, compound

Procedure

3-Nitro-phenol was reacted with 3-bromomethyl-benzonitrile according to the procedure from Example 199A substituting 3-bromomethyl-benzonitrile for 1-bromomethyl-3-fluoro-benzene then reduced according to the procedure from Example 199B to provide the title compound.

Sources & evidence

ORD record
ord-332bea38f15d46b0a20d6c66f2ba50b5
Source dataset
uspto-grants-2011_03
Patent number
US07915411B2

Reaction notes

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