4-[2-Amino-4-(4-methoxy-benzyloxy)-phenylsulfanyl]-phenol → 4-[4-Benzyloxy-2-(7-ethyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol

Participants

Role	Name	HCID	Charge
Reactant	4-[2-Amino-4-(4-methoxy-benzyloxy)-phenylsulfanyl]-phenol	HCID 66808407	—
Reactant	N'-(3-Cyano-6-ethyl-pyridin-2-yl)-N,N-dimethyl-formamidine	HCID 66808443	—
Reactant	N'-(3-Cyano-6-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine	HCID 66808573	—
Reactant	4-(2-Amino-4-benzyloxy-phenylsulfanyl)-phenol	HCID 66808597	—
Product	4-[4-Benzyloxy-2-(7-ethyl-pyrido[2,3-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol	HCID 66808581	—

Reaction Steps

The product from Example 27A was reacted with the product from Example 145A using the procedure from Example 10F substituting the product from Example 27A for the product from Example 10E and substituting the product from Example 145A for the product from Example 10B to provide the title product. 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.32 (t, J=7.72 Hz, 3H), 2.95 (q, J=7.72 Hz, 2H), 5.11 (s, 2H), 6.65 (d, J=8.82 Hz, 2H), 6.91-7.05 (m, 1H), 7.10 (d, J=8.46 Hz, 2H), 7.32-7.50 (m, 6H), 8.12 (d, J=6.99 Hz, 1H), 8.66-8.77 (m, 1H), 9.04 (d, J=8.82 Hz, 1H), 9.63 (s, 1H), 10.28 (s, 1H); MS (APCI) m/z 481 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07915411B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-f71179df9738447388916e9845b7b68f
Source note	uspto-grants-2011_03