反应详情

The product from Example 27A was heated at 130° C. in acetic acid with the product from Example 127A for 15 minutes, the mixture was then cooled to room temperature, the solvent removed and the residue purified by column chromatography on silica gel to provide the title product. 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.38 (s, 9H) 5.11 (s, 2H) 6.60-6.74 (m, 2H) 6.94 (d, J=7.35 Hz, 1H) 7.06-7.19 (m, 3H) 7.27-7.50 (m, 6H) 7.78 (d, J=8.09 Hz, 1H) 8.56 (s, 1H) 8.75 (s, 1H) 9.64 (s, 1H) 9.95 (s, 1H); MS (ESI+) m/z 509 (M+H)+.

1. customthe solvent removed
2. customthe residue purified by column chromatography on silica gel