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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 607352Generated: October 25, 2026

1-Ethynyl-4-phenoxybenzene → (S)-5-[(4-phenoxyphenyl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide

https://huagongshe.com/reaction/607352

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethynyl-4-phenoxybenzeneHCID 12788024—
Reactant(S)-5-bromo-N-[methyl(oxido)phenyl--sulfanylidene]nicotinamideHCID 86629466—
Product(S)-5-[(4-phenoxyphenyl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamideHCID 2495313468%

Reaction Steps

In a manner similar to that describe in Example 425 a mixture of (S)-5-bromo-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide and 1-ethynyl-4-phenoxybenzene were reacted to give the title compound as an off-white solid (95 mg, 68%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07915443B2
Source datasetuspto-grants-2011_03
ORD IDord-7d2070cfd4d24e3fb9fd999ec825432e
Source noteuspto-grants-2011_03