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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 607397Generated: October 30, 2026

4-Iodophenol → (S)-6-amino-5-[(4-hydroxyphenyl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamide

https://huagongshe.com/reaction/607397

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-IodophenolHCID 10894—
Reactant(S)-6-amino-5-ethynyl-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamideHCID 24954186—
Product(S)-6-amino-5-[(4-hydroxyphenyl)ethynyl]-N-[methyl(oxo)phenyl-lambda6-sulfanylidene]nicotinamideHCID 2495455262%

Reaction Steps

In a manner similar to that describe in Example 467, (S)-6-amino-5-ethynyl-N-[methyl(oxo)phenyl-λ6-sulfanylidene]nicotinamide and 4-iodophenol are converted to the title compound (41 mg, 62%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07915443B2
Source datasetuspto-grants-2011_03
ORD IDord-f5f872af315d46c2a14d408d978e811e
Source noteuspto-grants-2011_03