HCID 57657933, compound → HCID 24955628, compound

HRID 607407Notes

Reaction equation

HRID 607407 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:19]=1)[C:7]([N:9]=[S@@:10]([CH3:18])(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8].[CH3:20][N:21]1[C:25]([NH:26][C:27](=[O:36])[C:28]2[CH:33]=[CH:32][CH:31]=[C:30]([C:34]#[CH:35])[CH:29]=2)=[CH:24][C:23]([CH3:37])=[N:22]1>>[CH3:20][N:21]1[C:25]([NH:26][C:27]([C:28]2[CH:29]=[C:30]([C:34]#[C:35][C:2]3[CH:3]=[N:4][CH:5]=[C:6]([CH:19]=3)[C:7]([N:9]=[S@@:10]([CH3:18])(=[O:17])[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[O:8])[CH:31]=[CH:32][CH:33]=2)=[O:36])=[CH:24][C:23]([CH3:37])=[N:22]1

Participants

3

Reactant 2

HCID 57657933HCID 57657933, compoundHCID 86629466(S)-5-bromo-N-[methyl(oxido)phenyl--sulfanylidene]nicotinamide

Product 1

HCID 24955628HCID 24955628, compoundYield 61%

Procedure

In a manner similar to that described in Example 460 (step 2), (S)-5-bromo-N-[methyl(oxido)phenyl--sulfanylidene]nicotinamide (0.141 g, 0.418 mmol) and N-(1,3-dimethyl-1H-pyrazol-5-yl)-3-ethynylbenzamide (0.1 g, 0.418 mmol) were reacted to give the title compound (0.126 g, 61%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-67560d4a2f05455ea1b97b8565bb1970
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

Loading…