5-Bromonicotinic acid → HCID 57657855, compound

HRID 607417Notes

Reaction equation

HRID 607417 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[NH:16])=[O:15])=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[Br:19][C:20]1[CH:21]=[N:22][CH:23]=[C:24]([CH:28]=1)[C:25](O)=[O:26]>>[Br:19][C:20]1[CH:28]=[C:24]([C:25]([N:16]=[S:14]([C:11]2[CH:12]=[CH:13][C:8]([NH:7][C:6](=[O:18])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:9][CH:10]=2)([CH3:17])=[O:15])=[O:26])[CH:23]=[N:22][CH:21]=1

Participants

3

Reactant 2

HCID 887075-Bromonicotinic acidHCID 576578261027730-26-2

Product 1

HCID 57657855HCID 57657855, compoundYield 75%

Procedure

In a manner similar to that described in Example 480 (step 6), tert-Butyl[4-(S-methylsulfonimidoyl)phenyl]carbamate (0.141 g, 0.522 mmol) and 5-bromonicotinic acid (0.104 g, 0.522 mmol), were converted to the title compound (0.177 g, 75%).

Sources & evidence

ORD record
ord-02b90ea85a004c89806b0c0b31d173c0
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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