HCID 57657855, compound → HCID 57657966, compound

HRID 607418Notes

Reaction equation

HRID 607418 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]([N:10]=[S:11]([C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[CH:16][CH:15]=2)([CH3:13])=[O:12])=[O:9])[CH:5]=[N:6][CH:7]=1.[C:28]([C:30]1[CH:31]=[C:32]([NH:36][C:37]([C:39]2[N:40]([CH3:45])[N:41]=[C:42]([CH3:44])[CH:43]=2)=[O:38])[CH:33]=[CH:34][CH:35]=1)#[CH:29]>>[C:23]([O:22][C:21]([NH:20][C:17]1[CH:18]=[CH:19][C:14]([S:11]([CH3:13])(=[O:12])=[N:10][C:8](=[O:9])[C:4]2[CH:3]=[C:2]([C:29]#[C:28][C:30]3[CH:35]=[CH:34][CH:33]=[C:32]([NH:36][C:37]([C:39]4[N:40]([CH3:45])[N:41]=[C:42]([CH3:44])[CH:43]=4)=[O:38])[CH:31]=3)[CH:7]=[N:6][CH:5]=2)=[CH:15][CH:16]=1)=[O:27])([CH3:26])([CH3:25])[CH3:24]

Participants

3

Reactant 2

HCID 57657855HCID 57657855, compoundHCID 57657904N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

Product 1

HCID 57657966HCID 57657966, compoundYield 336.4%

Procedure

In a manner similar to that described in Example 460, tert-butyl (4-{N-[(5-bromopyridin-3-yl)carbonyl]-S-methylsulfonimidoyl}phenyl)carbamate (0.158 g, 0.349 mmol) and 2,5-dimethyl-2H-pyrazole-3-carboxylic acid (3-ethynyl-phenyl)-amide (0.125 g, 0.0524 mmol) were reacted to give the title compound (0.108 g, 51%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-f2db58ef9a094779a8fc5b384d73c51e
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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