3-(Methylamino)propane-1,2-diol → HCID 24955986, compound

HRID 607422Notes

Reaction equation

HRID 607422 reaction equation
[CH3:1][S:2]([C:30]1[CH:35]=[CH:34][C:33]([CH2:36][CH2:37][C:38](O)=[O:39])=[CH:32][CH:31]=1)(=[N:4][C:5]([C:7]1[CH:8]=[N:9][CH:10]=[C:11]([C:13]#[C:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]([C:24]3[O:25][CH:26]=[CH:27][C:28]=3[CH3:29])=[O:23])[CH:16]=2)[CH:12]=1)=[O:6])=[O:3].[CH3:41][NH:42][CH2:43][CH:44]([OH:47])[CH2:45][OH:46]>>[OH:47][CH:44]([CH2:45][OH:46])[CH2:43][N:42]([CH3:41])[C:38](=[O:39])[CH2:37][CH2:36][C:33]1[CH:32]=[CH:31][C:30]([S:2]([CH3:1])(=[O:3])=[N:4][C:5](=[O:6])[C:7]2[CH:12]=[C:11]([C:13]#[C:14][C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]([C:24]4[O:25][CH:26]=[CH:27][C:28]=4[CH3:29])=[O:23])[CH:16]=3)[CH:10]=[N:9][CH:8]=2)=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 27341223-(Methylamino)propane-1,2-diolHCID 24955983HCID 24955983, compound

Product 1

HCID 24955986HCID 24955986, compoundYield 35%

Procedure

In a manner similar to that described in Example 485, 3-[4-(S-methyl-N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}-ethynyl)pyridin-3-yl]carbonyl}sulfonimidoyl)-phenyl]propanoic acid (0.050 g, 0.090 mmol) and 3-methylamino-propane-1,2-diol (0.050 mL, 0.520 mmol) were reacted to give the title compound (0.020 g, 35%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-b548ea63c9a64a6685b3a4657c87f7fb
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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