1-[2-(2-Hydroxyethoxy)ethyl]piperazine → HCID 24956352, compound

HRID 607424Notes

Reaction equation

HRID 607424 reaction equation
[CH3:1][S:2]([C:30]1[CH:35]=[CH:34][C:33]([CH2:36][CH2:37][C:38]([OH:40])=O)=[CH:32][CH:31]=1)(=[N:4][C:5]([C:7]1[CH:8]=[N:9][CH:10]=[C:11]([C:13]#[C:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]([C:24]3[O:25][CH:26]=[CH:27][C:28]=3[CH3:29])=[O:23])[CH:16]=2)[CH:12]=1)=[O:6])=[O:3].[N:41]1([CH2:47][CH2:48][O:49][CH2:50][CH2:51][OH:52])[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1>>[OH:52][CH2:51][CH2:50][O:49][CH2:48][CH2:47][N:41]1[CH2:46][CH2:45][N:44]([C:38](=[O:40])[CH2:37][CH2:36][C:33]2[CH:34]=[CH:35][C:30]([S:2]([CH3:1])(=[O:3])=[N:4][C:5](=[O:6])[C:7]3[CH:12]=[C:11]([C:13]#[C:14][C:15]4[CH:20]=[CH:19][CH:18]=[C:17]([NH:21][C:22]([C:24]5[O:25][CH:26]=[CH:27][C:28]=5[CH3:29])=[O:23])[CH:16]=4)[CH:10]=[N:9][CH:8]=3)=[CH:31][CH:32]=2)[CH2:43][CH2:42]1

Participants

3

Reactant 2

HCID 1394361-[2-(2-Hydroxyethoxy)ethyl]piperazineHCID 24955983HCID 24955983, compound

Product 1

HCID 24956352HCID 24956352, compoundYield 47%

Procedure

In a manner similar to that described in Example 485, 3-[4-(S-methyl-N-{[5-({3-[(3-methyl-2-furoyl)amino]phenyl}-ethynyl)pyridin-3-yl]carbonyl}sulfonimidoyl)-phenyl]propanoic acid (0.050 g, 0.090 mmol) and 2-(2-piperazin-1-yl-ethoxy)-ethanol (0.030 mL, 0.180 mmol) were reacted to give the title compound (0.030 g, 47%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-adcffe9e3c3b45c2a90bc2967666867b
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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