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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 607453Generated: October 26, 2026

Ethanolamine → (S)-N-[{3-[(2-hydroxyethyl)amino]propyl}(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

https://huagongshe.com/reaction/607453

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanolamineHCID 700—
ReactantN-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamideHCID 76585264—
Product(S)-N-[{3-[(2-hydroxyethyl)amino]propyl}(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamideHCID 57657917—

Reaction Steps

In a manner similar to that described for Example 508, N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide and 2-hydroxyethylamine were converted to the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07915443B2
Source datasetuspto-grants-2011_03
ORD IDord-44120d62569f4784998dae9e9a6d3fe1
Source noteuspto-grants-2011_03