Thiomorpholine 1,1-dioxide → (S)-N-{[3-(1,1-dioxidothiomorpholin-4-yl)propyl](oxido)phenyl--sulfanylidene}-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	Thiomorpholine 1,1-dioxide	HCID 6484228	—
Reactant	N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide	HCID 76585264	—
Product	(S)-N-{[3-(1,1-dioxidothiomorpholin-4-yl)propyl](oxido)phenyl--sulfanylidene}-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide	HCID 57657888	—

Reaction Steps

In a manner similar to that described for Example 508, N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide and thiomorpholine-1,1-dioxide were converted to the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07915443B2
Source dataset	uspto-grants-2011_03
ORD ID	ord-99f8ef1589184e79bd08e12e9a53808f
Source note	uspto-grants-2011_03