HRID607461

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2760776

3-(Trifluoromethyl)piperidine

C6H10F3N

结构：Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S(=O)(CCCBr)c3ccccc3)c2)c1

HCID76585264

未命名化合物

PRODUCTS

生成物

结构：Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S(=O)(CCCN3CCCC(C(F)(F)F)C3)c3ccccc3)c2)c1

HCID57657831

未命名化合物

PROCEDURE

实验过程

In a manner similar to that described for example 508, N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-({3-[(3-methyl-2-furoyl)amino]phenyl}ethynyl)nicotinamide and 3-(trifluoromethyl)piperidine were converted to the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7ca638d8ea4c4f1086a68f57dd3590a2
来源数据集: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07915443B2
来源说明: uspto-grants-2011_03

反应 SMILES

Br[CH2:2][CH2:3][CH2:4][S:5](=[O:38])([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[N:6][C:7](=[O:31])[C:8]1[CH:13]=[C:12]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:23]([C:25]3[O:26][CH:27]=[CH:28][C:29]=3[CH3:30])=[O:24])[CH:17]=2)[CH:11]=[N:10][CH:9]=1.[F:39][C:40]([F:48])([F:47])[CH:41]1[CH2:46][CH2:45][CH2:44][NH:43][CH2:42]1>>[CH3:30][C:29]1[CH:28]=[CH:27][O:26][C:25]=1[C:23]([NH:22][C:18]1[CH:17]=[C:16]([C:15]#[C:14][C:12]2[CH:11]=[N:10][CH:9]=[C:8]([CH:13]=2)[C:7]([N:6]=[S:5](=[O:38])([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:4][CH2:3][CH2:2][N:43]2[CH2:44][CH2:45][CH2:46][CH:41]([C:40]([F:48])([F:47])[F:39])[CH2:42]2)=[O:31])[CH:21]=[CH:20][CH:19]=1)=[O:24]