Dimethylamine → HCID 86629487, compound

HRID 607467Notes

Reaction equation

HRID 607467 reaction equation
Br[CH2:2][CH2:3][CH2:4][S@:5](=[O:39])([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[N:6][C:7](=[O:32])[C:8]1[CH:13]=[C:12]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:23]([C:25]3[N:29]([CH3:30])[N:28]=[C:27]([CH3:31])[CH:26]=3)=[O:24])[CH:17]=2)[CH:11]=[N:10][CH:9]=1.[CH3:40][NH:41][CH3:42]>>[CH3:40][N:41]([CH3:42])[CH2:2][CH2:3][CH2:4][S@:5](=[O:39])([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[N:6][C:7](=[O:32])[C:8]1[CH:13]=[C:12]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([NH:22][C:23]([C:25]3[N:29]([CH3:30])[N:28]=[C:27]([CH3:31])[CH:26]=3)=[O:24])[CH:17]=2)[CH:11]=[N:10][CH:9]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 57657823HCID 57657823, compound

Product 1

HCID 86629487HCID 86629487, compound

Procedure

In a manner similar to that described for example 508, (S)-N-[(3-bromopropyl)(oxido)phenyl--sulfanylidene]-5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]nicotinamide and dimethylamine were converted to the title compound.

Sources & evidence

ORD record
ord-476ee87a8ab0412d8d1df7dd1b298a65
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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