5-Bromonicotinic acid → 5-((3-(3-Methylfuran-2-carboxamido)phenyl)ethynyl)nicotinic acid

HRID 607468Notes

Reaction equation

HRID 607468 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]([C:12]2[O:13][CH:14]=[CH:15][C:16]=2[CH3:17])=[O:11])[CH:6]=[CH:7][CH:8]=1)#[CH:2].Br[C:19]1[CH:20]=[N:21][CH:22]=[C:23]([CH:27]=1)[C:24]([OH:26])=[O:25]>>[CH3:17][C:16]1[CH:15]=[CH:14][O:13][C:12]=1[C:10]([NH:9][C:5]1[CH:4]=[C:3]([C:1]#[C:2][C:19]2[CH:20]=[N:21][CH:22]=[C:23]([CH:27]=2)[C:24]([OH:26])=[O:25])[CH:8]=[CH:7][CH:6]=1)=[O:11]

Participants

3

Reactant 2

HCID 887075-Bromonicotinic acidHCID 51337833N-(3-ethynylphenyl)-3-methylfuran-2-carboxamide

Product 1

HCID 576578475-((3-(3-Methylfuran-2-carboxamido)phenyl)ethynyl)nicotinic acid

Procedure

In a manner similar to that described for Example 480 (step 1), 3-methyl-furan-2-carboxylic acid (3-ethynyl-phenyl)-amide and 5-bromo nicotinic acid were reacted to provide the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-53f5253cc26e435bb974e07061913b63
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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