2-(Methylamino)ethanol → HCID 57657866, compound

HRID 607479Notes

Reaction equation

HRID 607479 reaction equation
C([C@H:3]([S:7]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)(=[N:9][C:10]([C:12]1[CH:13]=[N:14][CH:15]=[C:16]([C:18]#[C:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][C:27]([C:29]3[N:33]([CH3:34])[N:32]=[C:31]([CH3:35])[CH:30]=3)=[O:28])[CH:21]=2)[CH:17]=1)=[O:11])=[O:8])[C:4]([O-])=[O:5])C.[CH3:42][NH:43][CH2:44][CH2:45][OH:46]>>[CH3:34][N:33]1[C:29]([C:27]([NH:26][C:22]2[CH:21]=[C:20]([C:19]#[C:18][C:16]3[CH:15]=[N:14][CH:13]=[C:12]([CH:17]=3)[C:10]([N:9]=[S@@:7]([CH2:3][C:4]([N:43]([CH2:44][CH2:45][OH:46])[CH3:42])=[O:5])(=[O:8])[C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)=[O:11])[CH:25]=[CH:24][CH:23]=2)=[O:28])=[CH:30][C:31]([CH3:35])=[N:32]1

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 86629493HCID 86629493, compound

Product 1

HCID 57657866HCID 57657866, compound

Procedure

In a manner similar to that described in Example 534, (S)-Ethyl[N-({5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-phenylsulfonimidoyl]acetate and 2-methylaminoethanol were reacted to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ab946a70af0d4266bd9debadfa3b8184
Source dataset
uspto-grants-2011_03
Patent number
US07915443B2

Reaction notes

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