Imidazole → HCID 57857736, compound

Participants

Reaction Steps

9-(6-hydroxyhexyl)-9H-carbazole-3-carbaldehyde (12.0 g, 0.0406 mol) and dichloromethane (100 ml) were loaded into a three-neck flask, stirred, added with tert-butyldimethylsilyl chloride (7.35 g, 0.0487 mol) and imidazole (3.04 g, 0.0447 mol), and allowed to react at room temperature for 24 hours with stirring. The reaction product was transferred into a separate funnel, and was then added with water and ethyl acetate, after which the organic layer was isolated therefrom, dehydrated using sodium sulfate, and then distilled under reduced pressure. Then, the obtained viscous liquid was separated through silica column chromatography, thus obtaining 10.8 g of a liquid as the title compound.

Provenance & Evidence