HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-Methyl-2-[4-(trifluoromethyl)phenyl]cyclopropanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-methyl-2-[4-(trifluoromethyl)phenyl]cyclopropanecarboxylate | HCID 67047022 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Methyl-2-[4-(trifluoromethyl)phenyl]cyclopropanecarboxylic acid | HCID 62388158 | 94.4% |
Reaction Steps
The procedure described in Example 2I was followed using a THF (30 ml) solution of 14A (5.92 g, 21.7 mmol), 2M sodium hydroxide aqueous solution (22 ml) and MeOH (30 ml) to give 5.0 g (94% yield) of the title compound as white solids.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915448B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-b31f8f1e31714c4e87e66d77ec3f7303 |
| Source note | uspto-grants-2011_03 |