Piperidine → 6-tert-Butyl-2-piperidin-1-ylnicotinonitrile

HRID 607518ノート

反応式

HRID 607518 の反応式
[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7](Cl)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 8082PiperidineHCID 532788766-Tert-butyl-2-chloropyridine-3-carbonitrile

生成物 1

HCID 588735266-tert-Butyl-2-piperidin-1-ylnicotinonitrile収率 98%

実験手順

A mixture of 6-tert-butyl-2-chloronicotinonitrile (Tetrahedron 1965, 21, 2453-2467, 1.5 g, 7.7 mmol) and piperidine (15 ml, 176 mmol) was stirred for 20 hours at room temperature. Then the reaction mixture was evaporated to remove piperidine in vacuo to give the title compound (1.8 g, 98%).

後処理

  1. customThen the reaction mixture was evaporated
  2. customto remove piperidine in vacuo

出典と根拠

ORDレコード
ord-4bd494bca99d43a9856b707dc9b97b76
出典データセット
uspto-grants-2011_03
特許番号
US07915448B2

反応ノート

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