Piperidine → 6-tert-Butyl-2-piperidin-1-ylnicotinonitrile

HRID 607518Notes

Reaction equation

HRID 607518 reaction equation
[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7](Cl)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[C:1]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 532788766-Tert-butyl-2-chloropyridine-3-carbonitrile

Product 1

HCID 588735266-tert-Butyl-2-piperidin-1-ylnicotinonitrileYield 98%

Procedure

A mixture of 6-tert-butyl-2-chloronicotinonitrile (Tetrahedron 1965, 21, 2453-2467, 1.5 g, 7.7 mmol) and piperidine (15 ml, 176 mmol) was stirred for 20 hours at room temperature. Then the reaction mixture was evaporated to remove piperidine in vacuo to give the title compound (1.8 g, 98%).

Workup

  1. customThen the reaction mixture was evaporated
  2. customto remove piperidine in vacuo

Sources & evidence

ORD record
ord-4bd494bca99d43a9856b707dc9b97b76
Source dataset
uspto-grants-2011_03
Patent number
US07915448B2

Reaction notes

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