HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid monohydrate → HCID 59216307, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | Ethylorthoformate | HCID 53630039 | — |
| Reactant | Methyl 2-fluoro-4-(oxoacetyl)benzoate | HCID 59216303 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 59216307 | HCID 59216307 | — |
Reaction Steps
A mixture of methyl 2-fluoro-4-(oxoacetyl)benzoate (1.60 g), ethyl orthoformate (5.2 mL), p-toluenesulfonic acid monohydrate (70 mg) in toluene (20 mL) was heated under reflux for 3 h. After cooling, the mixture was concentrated. The residue was flash chromatographed on a silica gel column to give the desired product (0.63 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915408B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-426360c601344ead88315066ce8217ec |
| Source note | uspto-grants-2011_03 |