HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloropyridine → Tert-butyl 2-[methyl(pyridin-2-yl)amino]ethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloropyridine | HCID 7977 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Carbamic acid, N-[2-(methylamino)ethyl]-, 1,1-dimethylethyl ester, hydrochloride (1:1) | HCID 17750353 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Tert-butyl 2-[methyl(pyridin-2-yl)amino]ethylcarbamate | HCID 59216311 | — |
Reaction Steps
A solution of tert-butyl [2-(methylamino)ethyl]carbamate hydrochloride (0.30 g, 0.0014 mol), 2-chloropyridine (160 mg, 0.0014 mol), and triethylamine (300 μL, 0.0021 mol) in acetonitrile (5 mL) was heated at 90° C. overnight. The mixture was diluted with methanol, and purified by RP-HPLC (pH=10) to afford the desired product. Analytical LCMS: (M+H)+=252.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07915408B2 |
| Source dataset | uspto-grants-2011_03 |
| ORD ID | ord-18386b0514f442d0b5bfc1b09ef3fa4f |
| Source note | uspto-grants-2011_03 |