HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 607641Generated: October 29, 2026
4-Chloroanisole → 4-Methoxy-4'-trifluoromethyl-biphenyl
https://huagongshe.com/reaction/607641
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloroanisole | HCID 12167 | — |
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reagent | Water | HCID 962 | — |
| Reagent | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Catalyst | Bis(1,5-cyclooctadiene)nickel | HCID 6433264 | — |
| Catalyst | Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-(1,1'-biphenyl)-2-yl)phosphine | HCID 44233348 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Methoxy-4'-trifluoromethyl-biphenyl | HCID 11207478 | 9% |
Reaction Steps
pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate
Provenance & Evidence
| DOI | 10.26434/chemrxiv.14388557.v1 |
|---|
| Source dataset | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
| ORD ID | ord-7f39d0b144824fa086017b80b3dcaf5c |
|---|
| Source note | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
