HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 607642Generated: October 29, 2026
4-Chloroanisole → 4-Methoxy-4'-trifluoromethyl-biphenyl
https://huagongshe.com/reaction/607642
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloroanisole | HCID 12167 | — |
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reagent | Water | HCID 962 | — |
| Reagent | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Catalyst | Bis(1,5-cyclooctadiene)nickel | HCID 6433264 | — |
| Catalyst | Di-tert-butyl(2',4',6'-tris(propan-2-yl)-(1,1'-biphenyl)-2-yl)phosphane | HCID 11618717 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Methoxy-4'-trifluoromethyl-biphenyl | HCID 11207478 | 2% |
Reaction Steps
pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate
Provenance & Evidence
| DOI | 10.26434/chemrxiv.14388557.v1 |
|---|
| Source dataset | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
| ORD ID | ord-8e7e442ab9914f81b24f2e2fa1083a0b |
|---|
| Source note | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
