HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 607741Generated: October 30, 2026
4-Chloroanisole → 4'-Methoxy-2,4,6-trimethylbiphenyl
https://huagongshe.com/reaction/607741
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloroanisole | HCID 12167 | — |
| Reactant | 2,4,6-Trimethylbenzeneboronic acid | HCID 292184 | — |
| Reagent | Water | HCID 962 | — |
| Reagent | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Catalyst | Phosphine, cyclohexyldiphenyl- | HCID 80756 | — |
| Catalyst | Bis(1,5-cyclooctadiene)nickel | HCID 6433264 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4'-Methoxy-2,4,6-trimethylbiphenyl | HCID 10878873 | 20% |
Reaction Steps
pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate
Provenance & Evidence
| DOI | 10.26434/chemrxiv.14388557.v1 |
|---|
| Source dataset | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
| ORD ID | ord-dc6834eca58d422b97bcaebf3a13bb91 |
|---|
| Source note | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
