反应详情

The above described tert-butyl (5-fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methylcarbamate was stirred in CH2Cl2 (5 mL) and TFA (5 mL) overnight and concentrated in vacuo. The resulting residue was taken in EtOAc and washed with saturated NaHCO3. EtOAc layer was separated, dried with MgSO4 and concentrated in vacuo to afford desired (2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone in 42% yield over two steps.

1. concentrationTFA (5 mL) overnight and concentrated in vacuo
2. washwashed with saturated NaHCO3
3. customEtOAc layer was separated
4. dry with materialdried with MgSO4
5. concentrationconcentrated in vacuo