1-Benzofuran-4-carboxylic acid → HCID 71715782, compound

HRID 60781Notes

Reaction equation

HRID 60781 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([F:9])[CH2:5][N:4]1[C:10]([C:12]1[N:13]=[C:14]([CH3:23])[S:15][C:16]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:11].[O:24]1[C:28]2=[CH:29][CH:30]=[CH:31][C:32]([C:33](O)=[O:34])=[C:27]2[CH:26]=[CH:25]1>>[F:9][CH:6]1[CH2:5][N:4]([C:10]([C:12]2[N:13]=[C:14]([CH3:23])[S:15][C:16]=2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:11])[CH:3]([CH2:2][NH:1][C:33]([C:32]2[CH:31]=[CH:30][CH:29]=[C:28]3[O:24][CH:25]=[CH:26][C:27]=23)=[O:34])[CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 223241171-Benzofuran-4-carboxylic acidHCID 89739462(2-(Aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Product 1

HCID 71715782HCID 71715782, compound

Procedure

N-((5-Fluoro-1-(2-methyl-5-phenylthiazole-4-carbonyl)piperidin-2-yl)methyl)benzofuran-4-carboxamide was prepared by following general procedure A using (2-(aminomethyl)-5-fluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone and benzofuran-4-carboxylic acid. MS (ESI) 478 (M+H).

Sources & evidence

ORD record
ord-2cf9815c7aca40469afecdd0539ad850
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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