HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 607823Generated: October 31, 2026
4-Chloroanisole → Ethyl 4'-methoxy[1,1'-biphenyl]-4-carboxylate
https://huagongshe.com/reaction/607823
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloroanisole | HCID 12167 | — |
| Reactant | 4-Ethoxycarbonylphenylboronic acid | HCID 2734350 | — |
| Reagent | Water | HCID 962 | — |
| Reagent | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Catalyst | Bis(1,5-cyclooctadiene)nickel | HCID 6433264 | — |
| Catalyst | (2',4'-Diisopropyl-3-methoxy-6-methyl-6'-propyl-2-biphenylyl)[bis(2-methyl-2-propanyl)]phosphine | HCID 56641709 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Ethyl 4'-methoxy[1,1'-biphenyl]-4-carboxylate | HCID 2764348 | 0% |
Reaction Steps
pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate
Provenance & Evidence
| DOI | 10.26434/chemrxiv.14388557.v1 |
|---|
| Source dataset | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
| ORD ID | ord-c7b577c124204303bc843e42d5a2ba66 |
|---|
| Source note | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
