HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 607877Generated: October 30, 2026
4-Chloroanisole → Ethyl 4'-methoxy[1,1'-biphenyl]-4-carboxylate
https://huagongshe.com/reaction/607877
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloroanisole | HCID 12167 | — |
| Reactant | 4-Ethoxycarbonylphenylboronic acid | HCID 2734350 | — |
| Reagent | Water | HCID 962 | — |
| Reagent | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Catalyst | Bis(1,5-cyclooctadiene)nickel | HCID 6433264 | — |
| Catalyst | Phosphine, tris[3,5-bis(1,1-dimethylethyl)phenyl]- | HCID 10210777 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Ethyl 4'-methoxy[1,1'-biphenyl]-4-carboxylate | HCID 2764348 | 100% |
Reaction Steps
pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate
Provenance & Evidence
| DOI | 10.26434/chemrxiv.14388557.v1 |
|---|
| Source dataset | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
| ORD ID | ord-dbb7ac98388a4feebd87b87532b7d351 |
|---|
| Source note | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
