HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 607912Generated: October 30, 2026
1-Chloro-4-(trifluoromethyl)benzene → 4-Methoxy-4'-trifluoromethyl-biphenyl
https://huagongshe.com/reaction/607912
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| Reactant | (4-Methoxyphenyl)boronic acid | HCID 201262 | — |
| Reagent | Water | HCID 962 | — |
| Reagent | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Catalyst | Bis(1,5-cyclooctadiene)nickel | HCID 6433264 | — |
| Catalyst | Di-tert-butyl(2',4',6'-tris(propan-2-yl)-(1,1'-biphenyl)-2-yl)phosphane | HCID 11618717 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-Methoxy-4'-trifluoromethyl-biphenyl | HCID 11207478 | 18% |
Reaction Steps
pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate
Provenance & Evidence
| DOI | 10.26434/chemrxiv.14388557.v1 |
|---|
| Source dataset | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
| ORD ID | ord-56857aafe01f4d6692d6d4abdb0d4eaf |
|---|
| Source note | Ni-catalyzed Suzuki Miyaura cross-coupling |
|---|
